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降低凝血因子XI表达的双链核糖核酸及其修饰物和应用
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14Claims · 4 independent
§ Ⅰ
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Applicant
北京悦康科创医药科技股份有限公司; 杭州天龙药业有限公司
Inventor
黄泽傲; 宋更申; 杨硕; 许晨; 吴玉成; 田志康; 付锐; 于飞
IPC Classification
C12N 15/113 (2010.01)C12N 9/22 (2006.01)A61K 31/713 (2006.01)A61K 38/46 (2006.01)A61P 7/02 (2006.01)A61P 9/00 (2006.01)A61P 9/10 (2006.01)A61P 25/28 (2006.01)A61P 13/12 (2006.01)
本公开提供了降低凝血因子XI表达的双链核糖核酸及其修饰物和应用。细胞实验结果显示，本公开的寡核苷酸双链体能够显著抑制FXI基因的表达，可用于开发抗凝血药物。
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