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一种靶向脂质纳米颗粒复合物及其制备方法和应用
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12Claims · 6 independent
§ Ⅰ
Dossier Overview
Inventor
林金钟; 徐颖洁; 卢静; 刘燕; 姜婷; 顾浩; 李雪纯
Filing Date
Jun 30, 2026
Publication Date
Oct 20, 2026
IPC Classification
A61K 9/51 (2006.01)A61K 47/18 (2017.01)A61K 47/69 (2017.01)A61K 47/68 (2017.01)A61K 48/00 (2006.01)A61K 40/42 (2025.01)A61K 40/31 (2025.01)A61K 40/11 (2025.01)A61K 40/13 (2025.01)A61K 40/15 (2025.01)A61K 40/17 (2025.01)A61K 40/19 (2025.01)A61P 35/00 (2006.01)A61P 35/02 (2006.01)A61P 37/02 (2006.01)C12N 15/62 (2006.01)
本发明涉及一种靶向脂质纳米颗粒复合物及其制备方法和应用。所述复合物采用特定结构的可电离脂质（化合物LQ‑001至LQ‑007）作为tLNP的核心组分，能够特异性识别并结合特定细胞表面标志物，从而实现药物或核酸的有效递送，显著提升治疗效果。由此制备的靶向脂质纳米粒组合物能够在体内或体外将治疗性核酸或药物选择性递送至特定组织或细胞类型，大幅降低给药剂量与系统性副作用，实现对目标细胞的精准干预与治疗。
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