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脐带间充质干细胞外泌体在制备修复隐睾导致的血睾屏障损伤的药物中的应用
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10Claims · 6 independent
§ Ⅰ
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Inventor
齐进春; 贺妍; 杨昊璇; 王润隆; 杜蕾; 马子越; 薛文勇
Filing Date
Sep 16, 2026
Publication Date
Oct 20, 2026
IPC Classification
A61K 35/28 (2015.01)A61P 15/08 (2006.01)
本发明公开了脐带间充质干细胞外泌体在制备修复隐睾导致的血睾屏障损伤的药物中的应用。本发明首次发现脐带间充质干细胞(UMSCs)可停留于睾丸组织内并被生精小管内细胞吸收,修复大鼠隐睾模型行睾丸下降术后的血睾屏障损伤,促进生殖细胞增殖,改善生精功能。本发明为血睾屏障损伤提供的全新的治疗思路,在生殖系统疾病的治疗领域具有重要的临床意义和转化价值。
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