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作为WRN抑制剂的化合物及其应用

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9Claims · 4 independent
§ Ⅰ

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Applicant

南京圣和药业股份有限公司

南京圣和药业股份有限公司 · View all patentsPatent applicant records

Inventor

郁壮壮; 全旭; 张小猛; 白磊; 蒋硕

Filing Date

Apr 23, 2026

Publication Date

Oct 27, 2026

IPC Classification

C07C 381/10 (2006.01)C07D 213/81 (2006.01)C07C 317/46 (2006.01)C07D 295/088 (2006.01)C07D 309/32 (2006.01)C07D 211/90 (2006.01)A61P 35/00 (2006.01)A61K 31/4422 (2006.01)A61K 31/44 (2006.01)A61K 31/351 (2006.01)A61K 31/495 (2006.01)A61K 31/166 (2006.01)

本发明属于医药化学领域，涉及一类作为WRN抑制剂的化合物及其应用，具体地，本发明提供式(I)和式(II)所示的化合物或其药学上可接受的盐、异构体、溶剂化物、结晶或前药，它们的制备方法以及含有这些化合物的药物组合物和这些化合物或组合物用于治疗与WRN相关的疾病的用途。、

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