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抗亲环素A单抗及其在类风湿性关节炎治疗中的应用
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10Claims · 5 independent
§ Ⅰ
Dossier Overview
Inventor
刘文军; 孙蕾; 白晓园; 赵雨娜; 李和桥; 张鹤
Filing Date
Nov 7, 2023
Publication Date
Oct 27, 2026
IPC Classification
C12N 5/20 (2006.01)C07K 16/40 (2006.01)A61K 39/395 (2006.01)A61P 19/02 (2006.01)A61P 29/00 (2006.01)G01N 33/573 (2006.01)G01N 33/577 (2006.01)
本发明公开了抗亲环素A单抗及其在类风湿性关节炎治疗中的应用。本发明提供了分泌anti‑CypA单抗的杂交瘤细胞BQHA7，其保藏号为CGMCC No. 45101，还提供了所述杂交瘤细胞BQHA7分泌的anti‑CypA单抗。本发明的实验证明了，本发明提供了1种能分泌抗CypA单抗的杂交瘤细胞株，该杂交瘤细胞株能够分泌单抗BQHA7，此单抗BQHA7可以特异性识别CypA，对II 型胶原蛋白诱导的小鼠类风湿性关节炎（rheumatoid arthritis，RA）具有良好的治疗作用。
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