METHODS FOR PREPARING (2S,3R,4R)-4,5-DIHYDROXYISOLEUCINE DERIVATIVE AND INTERMEDIATES THEREOF
Dossier Overview
Applicant
INNER MONGOLIA UNIVERSITY; INNER MONGOLIA DUHE INNOVATION R & D TECH CO., LTD
Inventor
Guodu LIU; Zongwei LI; Xinlong YAN
IPC Classification
CPC Classification
Provided are methods for preparing a (2S,3R,4R)-4,5-dihydroxyisoleucine (DHile) derivative and intermediates thereof. Methods for preparing a series of intermediates of the (2S,3R,4R)-4,5-DHile derivative are provided, on the basis of which the (2S,3R,4R)-4,5-DHile derivative could be prepared. Specifically, a glycine derivative, benzophenone imine glycine tert-butyl ester (compound 1, with a structure shown in Formula 1) that is easy to be purchased through commercial channels and has a low price, is selected as a starting reaction raw material; the starting reaction raw material is subjected to asymmetric allylation, asymmetric dihydroxylation, and introduction or removal of protective groups to achieve efficient asymmetric synthesis of a target product.
Original (Chinese)
Provided are methods for preparing a (2S,3R,4R)-4,5-dihydroxyisoleucine (DHile) derivative and intermediates thereof. Methods for preparing a series of intermediates of the (2S,3R,4R)-4,5-DHile derivative are provided, on the basis of which the (2S,3R,4R)-4,5-DHile derivative could be prepared. Specifically, a glycine derivative, benzophenone imine glycine tert-butyl ester (compound 1, with a structure shown in Formula 1) that is easy to be purchased through commercial channels and has a low price, is selected as a starting reaction raw material; the starting reaction raw material is subjected to asymmetric allylation, asymmetric dihydroxylation, and introduction or removal of protective groups to achieve efficient asymmetric synthesis of a target product.
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