IMPROVED METHODS OF PREPARING DIFFERENT MESODERM CELL TYPES
Dossier Overview
Applicant
Children's Hospital Medical Center; RIKEN
Inventor
Aaron M. ZORN; Lu HAN; Keishi KISHIMOTO; Mitsuru MORIMOTO
IPC Classification
CPC Classification
Disclosed herein are improved in vitro methods of making splanchnic mesoderm cell types and subtypes thereof from pluripotent cells. These methods can be used to produced improved foregut- and hindgut-derived organoids containing enriched mesenchyme, which enhances organoid viability, growth, and maturation, both in in vitro culture and in vivo transplantation.
Original (Chinese)
Disclosed herein are improved in vitro methods of making splanchnic mesoderm cell types and subtypes thereof from pluripotent cells. These methods can be used to produced improved foregut- and hindgut-derived organoids containing enriched mesenchyme, which enhances organoid viability, growth, and maturation, both in in vitro culture and in vivo transplantation.
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