一种特戈拉赞中间体的合成方法
本发明提供一种特戈拉赞中间体的合成方法,所述特戈拉赞中间体合成方法包括:以1‑苄基‑4‑羟基‑2‑甲基‑1H‑苯并咪唑‑6‑羧酸为起始原料,依次经过酰胺化、与乙酰基进行酯化反应、催化氢化脱苄基,磺酸酯化,脱乙酰基保护得特戈拉赞中间体4‑羟基‑N,N,2‑三甲基‑1‑对甲苯磺酰基‑1H‑苯并[D]咪唑‑6‑甲酰胺。本申请采用先酰胺化再酯化反应,首先将高活性的羧基转化为稳定的酰胺,酰胺键在后续的酯化和氢化反应中都非常稳定,不会发生副反应。
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