Back to Search
Dossier
猪STING蛋白K61R突变体及其应用
InventionActive
8Claims · 4 independent
§ Ⅰ
Dossier Overview
Inventor
朱建中; 夏能文; 郑王龙; 陈南华; 姜森
IPC Classification
C07K 14/47 (2006.01)C12N 15/12 (2006.01)A61K 38/17 (2006.01)A61P 31/14 (2006.01)A61P 31/20 (2006.01)A61P 31/22 (2006.01)
本发明公开了一种猪STING蛋白K61R突变体及其应用,所述突变体为猪STING蛋白的第61位赖氨酸突变为精氨酸,所述猪STING蛋白的氨基酸序列如SEQ ID NO.1所示。本发明首次鉴定猪STING蛋白的种属特异性关键位点K61,该位点为猪特有、区别于其他物种,通过调控蛋白稳定性及下游信号转导,对ASFV、PRV、HSV‑1等病毒复制发挥关键负向调控作用;同时,K61位点可直接作为猪抗病毒育种的核心分子标记与靶向位点,为提升抗病育种研究效率提供重要支撑。
Sign in to read the full text
Claim 1 is shown. Create a free account to read all 8 claims, the full description, all drawings, translations and legal status.
- All claims
- Technical field
- Background
- Summary
- Drawing descriptions
- Detailed description
External Resources