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理性设计的肌肉嗜性腺相关病毒载体及其应用

InventionUnknown
15Claims · 8 independent
§ Ⅰ

Dossier Overview

Applicant

信中医药科技（北京）有限公司

信中医药科技（北京）有限公司 · View all patentsPatent applicant records

Inventor

胡晗阳; 肖啸

Filing Date

Apr 10, 2026

Publication Date

Oct 20, 2026

IPC Classification

C07K 14/015 (2006.01)C07K 19/00 (2006.01)C12N 15/864 (2006.01)C12N 15/35 (2006.01)C12N 15/62 (2006.01)C12N 5/10 (2006.01)A61K 48/00 (2006.01)A61P 21/00 (2006.01)A61P 21/04 (2006.01)A61P 9/04 (2006.01)A61P 9/10 (2006.01)

本发明描述了一类理性设计的新型工程化腺相关病毒（AAV）衣壳。本发明的AAV衣壳变体比母体AAV能够更高效、更特异地转导全身肌肉组织。本发明的AAV衣壳变体可用于生产rAAV载体，以更高表达水平和/或更低剂量优先递送目的基因至肌肉组织。

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